"The Financially Fragile Firm: Is There a Case for It in the 1920s?"

This paper is an empirical investigation of Minsky's hypothesis in the U.S. consumer durables sector during the 1920s. The first section of the paper briefly describes Minsky's financial fragility hypothesis, while the second sketches a brief economic historical background of the 1920s in the U.S. The third section introduces the methodology utilized and the fourth presents the results of the analysis. In the conclusion the findings and their implications are summarized.

Cancer complicating systemic lupus erythematosus--a dichotomy emerging from a nested case-control study

We determined whether any individual cancers are increased or decreased in a cohort of 595 patients with systemic lupus erythematosus (SLE) followed for up to 32 years at the University College London Hospitals Lupus Clinic, looking for any associated clinical or serological factors and the prognosis after cancer diagnosis

A model problem for conformal parameterizations of the Einstein constraint equations

We investigate the possibility that the conformal and conformal thin sandwich (CTS) methods can be used to parameterize the set of solutions of the vacuum Einstein constraint equations. To this end we develop a model problem obtained by taking the quotient of certain symmetric data on conformally flat tori. Specializing the model problem to a three-parameter family of conformal data we observe a number of new phenomena for the conformal and CTS methods. Within this family, we obtain a general existence theorem so long as the mean curvature does not change sign. When the mean curvature changes sign, we find that for certain data solutions exist if and only if the transverse-traceless tensor is sufficiently small. When such solutions exist, there are generically more than one. Moreover, the theory for mean curvatures changing sign is shown to be extremely sensitive with respect to the value of a coupling constant in the Einstein constraint equations.Comment: 40 pages, 4 figure

A study of electronic packages environmental control systems and vehicle thermal systems integration Quarterly report, Nov. 1966 - Jan. 1967

Heat balances of combined astrionic equipment and thermal conditioning subsystem of environmental control system, and vehicle configuration

A non-existence result for a generalization of the equations of the conformal method in general relativity

The constraint equations of general relativity can in many cases be solved by the conformal method. We show that a slight modification of the equations of the conformal method admits no solution for a broad range of parameters. This suggests that the question of existence or non-existence of solutions to the original equations is more subtle than could perhaps be expected.Comment: minor changes from previous versio

Asymptotically Hyperbolic Non Constant Mean Curvature Solutions of the Einstein Constraint Equations

We describe how the iterative technique used by Isenberg and Moncrief to verify the existence of large sets of non constant mean curvature solutions of the Einstein constraints on closed manifolds can be adapted to verify the existence of large sets of asymptotically hyperbolic non constant mean curvature solutions of the Einstein constraints.Comment: 19 pages, TeX, no figure

Resonant Interactions Between Protons and Oblique Alfv\'en/Ion-Cyclotron Waves

Resonant interactions between ions and Alfv\'en/ion-cyclotron (A/IC) waves may play an important role in the heating and acceleration of the fast solar wind. Although such interactions have been studied extensively for "parallel" waves, whose wave vectors ${\bf k}$ are aligned with the background magnetic field ${\bf B}_0$, much less is known about interactions between ions and oblique A/IC waves, for which the angle $\theta$ between ${\bf k}$ and ${\bf B}_0$ is nonzero. In this paper, we present new numerical results on resonant cyclotron interactions between protons and oblique A/IC waves in collisionless low-beta plasmas such as the solar corona. We find that if some mechanism generates oblique high-frequency A/IC waves, then these waves initially modify the proton distribution function in such a way that it becomes unstable to parallel waves. Parallel waves are then amplified to the point that they dominate the wave energy at the large parallel wave numbers at which the waves resonate with the particles. Pitch-angle scattering by these waves then causes the plasma to evolve towards a state in which the proton distribution is constant along a particular set of nested "scattering surfaces" in velocity space, whose shapes have been calculated previously. As the distribution function approaches this state, the imaginary part of the frequency of parallel A/IC waves drops continuously towards zero, but oblique waves continue to undergo cyclotron damping while simultaneously causing protons to diffuse across these kinetic shells to higher energies. We conclude that oblique A/IC waves can be more effective at heating protons than parallel A/IC waves, because for oblique waves the plasma does not relax towards a state in which proton damping of oblique A/IC waves ceases

Anti-IFNαR Mabs for the treatment of systemic lupus erythematosus

INTRODUCTION: The type 1 interferon pathway is known to play a role in the immunopathology of systemic lupus erythematosus (SLE). As a result, biologic agents targeting this pathway have been developed and are currently being investigated in clinical trials. AREAS COVERED: We review the biologic agents which have been developed to antagonize type I interferons in SLE. We focus on anifrolumab, a type I interferon receptor antagonist, and consider the complexities of defining efficacy in SLE clinical trials. EXPERT OPINION: Anifrolumab shows promise as an addition to the SLE therapeutic armamentarium. Despite discordant results between its two phase III studies, there is a convincing suggestion of benefit in both trials to encourage the view that this approach might be effective. Data acquired thus far look particularly useful for cutaneous disease. We await data on its effect on renal, pulmonary, cardiac, and central nervous system involvement, on patient reported outcomes, and its safety and efficacy with long-term use

The constraint equations for the Einstein-scalar field system on compact manifolds

We study the constraint equations for the Einstein-scalar field system on compact manifolds. Using the conformal method we reformulate these equations as a determined system of nonlinear partial differential equations. By introducing a new conformal invariant, which is sensitive to the presence of the initial data for the scalar field, we are able to divide the set of free conformal data into subclasses depending on the possible signs for the coefficients of terms in the resulting Einstein-scalar field Lichnerowicz equation. For many of these subclasses we determine whether or not a solution exists. In contrast to other well studied field theories, there are certain cases, depending on the mean curvature and the potential of the scalar field, for which we are unable to resolve the question of existence of a solution. We consider this system in such generality so as to include the vacuum constraint equations with an arbitrary cosmological constant, the Yamabe equation and even (all cases of) the prescribed scalar curvature problem as special cases.Comment: Minor changes, final version. To appear: Classical and Quantum Gravit